At the DNA level of the subjects rejuvenated on average for 2.5 years.
Researchers from the University of California (USA) conducted a medical experiment in which participants become “younger” at the DNA level after taking prescription medications, according to the Chronicle.info with reference on the Letters.
“A small clinical study in California showed that it is possible to reverse epigenetic clock of the organism, which measure the biological age of the person”, – says the publication.
The epigenetic clock is the totality of epigenetic marks DNA to determine the biological age of a tissue, cell or organ. Participants during the reception of a number of drugs have reduced their biological age, determined by these special DNA markers.
So, within one year, nine volunteers took a “cocktail” of three common drugs: growth hormone and two drugs from diabetes. As a result, each of them “younger,” on average 2.5 years at the DNA level. The immune system of the participants also showed signs of rejuvenation.
Similar results were absolutely unexpected for the authors of the study. Initially they only wanted to test the effect of concurrent use of three widely used medications on the human immune system.
The researchers caution that the results are preliminary, as testing had a modest scale, and there was no control group.
“I expected to see a slowdown (bio – ed) hours, but not the reverse. It all looked very futuristic,” – said one of the authors of the study, a genetics Professor Steve Horvath.
As explains the edition, the biological age of a person defines a set of DNA markers that change with aging (epigenetic clock). It reflects the functional state of the organism and can get ahead of the calendar age of a person, and to keep up with him.
In recent decades, scientists have tried to figure out a way to slow the biological clock and thereby prolong youth.
However, conducted in the U.S. the experiment was initiated with a different purpose: the scholars intended to check how safe it is to use injections of HGH for tissue repair thymus. The latter is located in the upper part of the chest and plays a critical role in the immune system.
Earlier studies have been conducted on animals, which showed that growth hormone assists in the regeneration of the gland, but it provokes the development of diabetes.
Therefore, when the experiment was conducted on humans, along with injections of growth hormone participants were prescribed two anti-diabetic drug Metformin and prasteron. The research was led by immunologist from Los Angeles Gregory Fahy.
9 participants (white males, aged 51 to 65 years) during the year, taking regular blood tests and also had an MRI (at the beginning and at the end of the study).
As it turned out, the blood values have improved for all participants. Seven of them really happened tissue regeneration of the thymus.
Subsequently, Gregory Fahy came up with the idea to show the results of their work to Steve Horvath, who has been researching the biological age.
In the end, Horvath found that the biological age of all participants in the experiment significantly decreased. Six men this effect persisted six months after the end of the experiment.
Now the researchers plan a larger scale study that will involve people of different age and ethnic groups.