Scientists have developed a new technique of growing brain cells

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Учёные разработали новый метод выращивания клеток мозгаThis technique will be widely adopted both in basic science and in the medical industry.

Scientists have developed a new technique more quickly and at lower cost-producing cells of the human brain from induced pluripotent stem cells in the laboratory.

These neurons are then used to test new drugs (e.g., drugs to treat Alzheimer’s disease).

When researchers find new drugs, particularly for the treatment of Alzheimer’s disease, these funds should be to begin with tested in human cells to confirm their effectiveness for patients. Historically, these tests are conducted on cancer cells, which are often biologically different from nervous.

As explained by Li gang, a researcher from the Gladstone Institutes (Gladstone Institutes), the problem is: neurons real people can’t “survive” in a test tube, so scientists have to create the nerve cells in the laboratory. However, it is not so simple.

Professionals often use induced stem cells (claim); claim get in the reprogramming of skin cells into stem, which subsequently can be transformed into any cell type of the body.

In the present work, a claim used to create nerve cells and glial cells, as they are associated with a neurodegenerative disease. The neurons derived from the lawsuit would serve as an excellent material for testing new drugs. However, the process of production of such cells is complicated and expensive. Most modern methods are able to create a heterogeneous (different from each other) cells; and the use of such cells prevents to obtain reliable results for drug screening.

Michael ward, a researcher from the National institutes of health (National Institutes of Health), figured out how it would be possible to fix this. He used a method of production claim, developed at Stanford, and suggested that if to simplify and to bring it under greater control, it is possible to improve the method create of the brain cells in the laboratory. The results of the work briefly reported at the Gladstone Institutes.
Growing brain cells in the lab: new mattward with his colleague, Chao Wang discovered how to change the genetic structure of cells to produce thousands of neurons from the same suit; thus it was possible to create identical, homogeneous cells. A team of scientists continued to improve the technique. The researchers were able to simplify it to two steps that helped then more accurately control the number of produced cells in the brain and is easier to reproduce the results of one experiment in the future.

In addition, the new technique also allowed greatly speed up the process. If he had taken a few months, this time Gan and colleagues were able to obtain large quantities of nerve cells for 1-2 weeks, and a month later they were functionally active neurons.

After that, the scientists, creating human neurons from the lawsuit, has developed a platform to study medication and analyzed 1 280 components. The scientists wanted to identify components that would reduce the level of Tau protein in the brain (this is one of the most promising approaches in the treatment of Alzheimer’s disease; it may lead to the development of new drugs).

Thus, the scientists were able to find a more economical method of production of a large number of neurons, which is held only in two simple steps. Gan hoped that this technique will be widely adopted both in basic science and in the medical industry.

The results of the study are described in detail in an article published in the journal Stem Cell Reports.

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