The researchers changed the structure of the compound.
Alcoholism leads to devastating consequences for health, relationships and to a fulfilled human life. Scientists have developed a new drug that can weaken the effect of alcohol on the “reward system” of the brain. They report their findings in the journal ACS Journal of Medicinal Chemistry.
Alcoholism is a disease that is the result of addiction to drink alcohol often and in excessive amounts.
Alcohol enters the brain and interacts with neurotransmitters and their receptors, including the system of “remuneration”. This causes a feeling of pleasure, relaxation and traction. Existing drugs for the treatment of alcohol depresses the system “rewards”, but the effect is not permanent and the drugs have serious side effects.
Chunyang Jin (Jin Chunyang) with co-authors of the study focus on the protein receptor GPR88, which prevails in the cells of the brain related to reward. Previous research on mice genetically modified with the absence of GPR88, showed that these animals were petrobelli alcohol more than a normal mouse. This led to the fact that the researchers wondered whether a drug that stimulate GPR88, to reduce the craving for alcohol. Earlier they have developed a synthetic small molecule that activates the GPR88 in vitro. However, this molecule could not effectively cross the blood brain barrier.
They created a molecule RTI-13951-33, which was stronger selektivnoe and could penetrate the blood brain barrier. When the rats were given RTI-13951-33, they drank less alcohol before received the drug. That is the drug level of alcohol consumption was higher. Rats, on the contrary, began to consume more sugar water with the same frequency that the drug or without him.
The researchers say that they are now studying the molecule as modified mice and those that lack the receptor GPR88.
The authors of another study claim that alcohol increases mortality of the young generation of mice infected with the tuberculosis bacterium.