Named a way to prevent baldness

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Назван способ предотвратить облысениеThe trial was conducted only on mice.

Scientists at the Johns Hopkins University (USA) showed that the synthetic compound D-PDMP is able to stop hair loss, their discoloration and inflammation of the skin. Experimental drug stops the fat synthesis of glycosphingolipids (GSL), which are involved in the activation of inflammatory processes.

It is known that mice that eat food high in fat and cholesterol, early signs of aging. This mechanism involves the GSL, which are found in keratinocytes — cells of the outer layer of the skin. To find out how changes in the content of glycosphingolipids affect the skin condition and can D-PDMP (D-Treo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) to bring the disorders, scientists have created genetically modified mice as an animal model of atherosclerosis.

One group of rodents from 12 weeks of age were fed with food rich in fat and cholesterol, and the second regular food. The first started to show signs of aging, including loss of fur and the emergence of pockets of inflammation.

Animals at 20 weeks of age began to give different doses of D-PDMP in the form of capsules or solution. It turned out that 1-10 milligrams of drug per kilogram of body weight for 16 weeks to significantly improve condition of the skin. However, in cells decreased the content of glycosphingolipid lactosylceramide, activating the inflammatory response.

Although the trial was conducted only on mice, scientists believe that similar results would be observed in humans. Specialists intend to test this hypothesis in future studies.

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