In the new study States that people with gum disease are at increased risk of developing rheumatoid arthritis (RA).
The researchers explained that the autoimmunity associated with RA, is characterized by an antibody response citrullinaemia proteins and oral bacteria Porphyromonas gingivalis (Pg) is the only pathogenic agent of a person who, as we know, expresses an enzyme that generates proteins citrullinaemia.
“Our results support the hypothesis that local inflammation on mucous surfaces such as the gums, can be a major trigger for the systemic autoimmunity observed in RA. We found that RA-associated antibodies such as anticitrulline protein antibodies are present long before any signs of joint diseases. This suggests that they are formed in places outside of the joints,” said study co-author Kulveer Mankia from the Institute of rheumatic and musculoskeletal medicine Leeds.
The study included 48 people who had a positive response to anticitrulline protein antibodies and musculoskeletal symptoms, but without clinical synovitis, and 26 patients with RA and 32 healthy person.
Scientists have made DNA from subgingival plaque near the gums of each participant and used it to measure levels of three types of bacterial Pg and Aggregatibacter actinomycetemcomitans (Aa) and Filifactor Alocis.
The results of the study showed that people at risk of RA, showed an increased number of bacteria Pg and Aa. However, only Pg was associated with an overall prevalence of gum disease.