Created a new way to edit DNA


The new technology is called LEAPER.

Chinese scientists have created a new technology that accurately and efficiently edit the human genome.

A new method based on the use of RNA and is more accurate than analogs, reported the online edition of the with reference to NV.

In recent years, the CRISPR/Cas9 and other technology for editing genomes of higher organisms had a great impact on the development of Biomedicine and other fields of science. In particular, CRISPR/Cas9 is based on the immune system of bacteria. The basis of this molecular system is of particular sections of bacterial DNA, clustered short palindromic repeats, or CRISPR, and also a bacterial protein called Cas9.

Using CRISPR/Cas9 to correct a wrong sequence genomes and thus to cure hereditary human diseases. But, nevertheless, as reported by a senior researcher from the Institute of life Sciences, PU Wei Wensheng, due to a number of shortcomings, the technology of CRISPR/Cas9 has not yet been applied in clinical treatment of diseases and needs to be improved.

Technology is not accurate enough. This means that due to the incorrect editing can increase the risk of immunological damage. The problem, in his opinion, is that the creation of a system depends on a foreign protein.

Ribonucleic acid (RNA) is a biopolymer, in the nucleotide sequence which may be written the genetic information. Scientific group under the leadership of Wei Wensheng found that editing the wrong genes, it is sufficient to enter a specially created RNA-guide and it does not need the participation of foreign protein.

The new technology is called LEAPER (leveraging programmable for endogenous ADAR editing of RNA).

Such advantages of technology LEAPER, both the efficiency and the accuracy has already been proven in experiments. With its help, the researchers have successfully fixed the defective cells in patients with the syndrome of Hurler.


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